Weesperplein is an Metro station in the city centre of Amsterdam. It is located betwween two canals on the southeastern edge of the Amsterdam canal ring. Weesperplein is a major transfer hub for Metro and Tram routes. As it is located close to the newly developed Roeterseiland campus of the University of Amsterdam, the destination "Universiteit" (English: University) has been added to automated station announcements on the trains.

The station opened in 1977 and is currently served by three routes: Orange 51, Red 53  and Yellow 54.

When the station opened, it served as the temporary northern terminus for the metro routes before the extension to Centraal Station was completed in 1980.

This Metro station is only accessible with an OV-chipkaart or GVB Travel Pass.

Underneath the station in operation is another, unused station level. It was meant for the never-built East-West metroline. In the 1970s and 1980s the space was prepared for use as a nuclear shelter. In the late 2000s all the equipment has been removed.